The 26-year-old's villainous alter ego Clare Devine was last seen on the Channel 4 soap in May, when she murdered Warren Fox (Jamie Lomas) in the show's dramatic Stunt Week 2009.
Speaking to Take 5 magazine, Bissix explained: "It was great to go back and see everyone because I lived up there for two years when I was first in the show and really missed everyone when I left.
"You really can't get much better than playing a psychotic murderer turning up in her ripped tights and pouring petrol over everything."
On the possibility of another return, she added: "It depends whether they need someone else to be killed off! I'm just happy to get regular work but I've really enjoyed being a part of Hollyoaks."
Bissix also claimed that there is a chance she could soon reprise her role as Clare Bates in EastEnders.
She commented: "When I left about six months ago they said they were thinking of bringing the character back in a year or so, but it's one of those things. I'll just have to wait and see."
Bissix has also been eyeing a continued career in reality TV, recently discussing her desire to star on Celebrity Come Dine With Me following her stints in Dancing On Ice and Celebrity Masterchef.