The actress's alter ego Carmel McQueen tied the knot with her ongoing love interest Calvin Valentine (Ricky Whittle) in 2008, but cracks in their relationship soon began to show and led to a break-up this year.
In an interview with DS, Merna revealed: "Me and Ricky wish, we really wish [they'd get back together], because we absolutely love working together. We love the characters together.
"But there is something coming up where there's going to be a big, big heartache for Carmel and I think that's going to be the final straw. It'll be 'never again'."
Last year, the 25-year-old had admitted that she wanted to see Carmel and Calvin settling down to enjoy their marriage.
Speaking at the time, she added: "They are a popular couple and if you ask me they are the best in the show - but I guess I would say that."
Carmel is seen facing more trouble in spinoff Hollyoaks Later tonight as she ends up behind bars in London. The final episode airs at 9pm on E4.
> Click here to watch our full interview with Gemma Merna