The 27-year-old, who has played fame-hungry Steph Cunningham in the Channel 4 teen serial since March 2000, will bow out of the programme in dramatic style towards the end of the year.
With Steph having just received the devastating news that she has cervical cancer, details pertaining to her exit story remain tightly under wraps.
It is therefore uncertain whether she will be given the 'all-clear', whether she will lose her battle with the life-threatening disease or whether she will bow out as part of a totally different storyline.
Speaking of her decision to leave, Stenson said: "Leaving Hollyoaks is one of the most difficult decisions I have ever made. It has been my dream job for ten years and I shall miss all of the fantastic friends I have made in the cast and crew."
She added: "I am very sad to leave but I'm ready for new challenges and I'm looking forward to pursuing a career in musical theatre."
Producer Paul Marquess commented: "We are very proud of the cervical cancer story-line and Hollyoaks' ability to bring a sweet and humorous tone to such a tragic story.
"Viewers can look forward to the return of 'Stephanie De La Dean' as Steph revisits her desire for fame and stardom in a bid to cope with her illness. We also hope that the message of early detection for cervical cancer reaches our young audience. "
He went on: "We are obviously very sad to see Steph go - she has been a much-loved character on the show for a decade, but we wish Carley all the best for a very bright and successful career."
Over the years, Stenson's character has been involved in a number of the show's big storylines, including being diagnosed with epilepsy, the death of her husband Max on their wedding day and Niall Rafferty's psychotic revenge.