The actor films his final scenes for the Channel 4 show in October after a year back on screen in the role of Warren Fox.
Speaking of the news, Lomas told New magazine that he is bowing out of his own accord because he wants to pursue other projects.
"Last time I left, the recession hit and there wasn't much being made," the 31-year-old explained. "It's starting to pick up and I wanted to give it another crack of the whip. I want something completely different to Warren to show people I'm versatile."
Asked whether Hollyoaks bosses will leave the door open for his villainous character, he replied: "I would like to think they would. I'll have to wait and see."
However, Lomas ruled out a permanent move to the US to find acting work, insisting that his children and fiancée Kym Marsh come first.
"I've got my kids here. Moving out there permanently is out of the question," he said. "Yeah, I'd love to go out and do a pilot season because it's always been a dream of mine. Kym has been nothing but 100% behind me. That's the way a partnership is.
"In terms of people saying she's going to lose me to Hollywood, that's nonsense. We've just bought a house, we've got a baby."
However, show producers lured Lomas back late last year, devising a shock storyline which saw Warren return to the village to wreak havoc.
Warren's recent plotlines have seen him embark on a relationship with glamour girl Mitzeee and clash with business partner Brendan Brady.
Read the full story in this week's New magazine - out today.
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