The actor plays Warren Fox, who was finally arrested during last night's episode (December 23) for Louise Summers's murder - which he committed back in December 2008.
© Lime Pictures
Lomas had previously left Hollyoaks in 2009 when his character was caught in a fire started by Clare Devine, but returned the following year.
"It was quite emotional filming my last scenes," he told E4. "I mean, it was emotional the last time I filmed them, but it's kind of closure this time. I think I had to come back to end it finally.
"It's a really dark storyline to go out on. It's going to be exciting stuff. It was sad to say goodbye, I'm going to miss everyone, but onwards and upwards hopefully."
Speaking of a potential return to Hollyoaks, he said: "Never say never. I didn't think I'd make a return after last time and I did, so never say never. I would like to do a little guest appearance in future."
Lomas's partner Kym Marsh recently returned to Coronation Street following the birth of their daughter Polly in March.
Watch Jamie Lomas discuss his Hollyoaks exit below:
