The actress - who plays Lynsey Nolan in the Channel 4 soap - said that although she misses her family and friends while filming, she is also enjoying her time away from Northern Ireland.
"Everybody's always at the end of a phonecall and my friends were over at the weekend - and my mum's coming over in the next few weeks," she told What's On TV.
"I miss the closeness and the familiarity of home but I feel settled here in Liverpool and it's my home for the foreseeable future.
"The whole thing for me has been a whirlwind. I always say when you start on Hollyoaks you don't just get a job, you get a whole lifestyle."
Hassan recently returned to Belfast to film her role in BBC drama The Fall alongside her Hollyoaks co-stars Emmett Scanlan and Bronagh Waugh.
"I've wanted to come back to Belfast and do something for a while, whether it was a play or a film or a series like The Fall and it was lovely to fly back to Belfast and I'm able to stay at my mum's house while I'm filming.
"It's funny - obviously I was over the moon because me, Emmett and Bronagh are all in Hollyoaks together playing kind of a family so it was amazing for us finding out the news kind of consecutively that we'd got parts in The Fall.
"We're all over the moon that we all ended up in it but randomly our paths don't really cross that much in The Fall. I was filming a scene with Emmett yesterday but our characters didn't know each other."
Crime drama The Fall starring Gillian Anderson debuts this winter on BBC Two in the UK.
Karen Hassan recently said that she wants Hollyoaks serial killer Silas Blissett to make a dramatic return to the village.