Esther Bloom (Jazmine Franks) and George Smith (Steven Roberts) will become interns at the fashion magazine's headquarters, in a plot which will play out on screen next month.
From Monday, July 9 to Friday, July 13, the Channel 4 teen soap - set in Liverpool - will relocate to Company's London offices.
Victoria White, editor of the magazine, will guest star in the show as herself.
Both Hollyoaks characters will struggle to cope independently in London, with Esther nearly ending her career by ruining a feature piece.
Meanwhile, George will embark on an office romance with fellow intern Ryan, who will be played by George Evans.
Esther and George's friendship will also be challenged in the special week.
Hollyoaks airs on weeknights at 6.30pm on Channel 4, with first-look episodes on E4 at 7pm. Get the Inside Soap magazine on your iPhone or iPad