The actress has landed the part of Maxine Minniver, who is the sister of established character Mitzeee (Rachel Shenton).
Maxine is billed as a "confident, lively and flirtatious bombshell", who lives her life on the edge and can spot an opportunity a mile off.
The savvy newcomer is not afraid to take risks, and has been tipped to cause fireworks as she makes her mark on Mitzeee's turf in the village.
Sanderson commented: "Being a member of the Hollyoaks team has so far been an absolute pleasure, and I am excited about what the future holds for my character. I feel very lucky to be part of such a wonderful show and to be working with an amazing team."
The 28-year-old is best known for playing Candice Stowe on Coronation Street between 1999 and 2005. She also played Dawn Bellamy on Heartbeat.
Maxine's first Hollyoaks scenes will air on Tuesday, November 6 at 6.30pm on Channel 4.