Tragedy strikes in the soap in just under a fortnight, when a mini-bus driven by Maddie Morrison (Scarlett Bowman) accidentally drives into the dual wedding celebrations of Tony (Nick Pickard), Cindy(Stephanie Waring), Ste (Kieron Richardson), and Doug (PJ Brennan).
The mini-bus is filled with the soap's teen characters, who are setting off to Scotland for Ruby (Anna Shaffer) and Jono's (Dylan Llewellyn) wedding. Maddie drives the vehicle, which unbeknownst to her has faulty brakes, into the party after swerving to avoid Ste's young daughter Leah when she steps out in front of the bus.
E4 has uploaded a spectacular new promo for the storyline, alongside a making-of for the 60-second spot.
Previous reports have suggested that at least two characters are set to die in the accident, although the identities are being kept a secret up until the date of transmission.
The disaster has also been tipped to "reveal secrets and lies that many had fought hard to keep hidden".
The dramatic week on Hollyoaks begins on Monday, November 12 at 6.30pm on Channel 4.
Watch the new promo below:
Watch the making-of clip below: