Cindy, played by Stephanie Waring, finds herself in the firing line after her affair with Jacqui's late husband Rhys is finally exposed over the festive season.
Viewers will see the drama unfold after Jacqui invites Cindy and Tony over to the McQueen house for Christmas lunch.
Although the atmosphere stays cheerful for a while, Jacqui later makes a devastating discovery when she looks through Rhys's phone and finds a video of him in bed with Cindy.
Discussing her character's subsequent rage, Claire Cooper - who plays Jacqui - told TV Times: "She let Cindy into her life - she even helped Jacqui with the funeral. She wants justice and she doesn't care if Cindy is dead."
Tony and Myra are soon left stunned when they find Cindy unconscious in the McQueens' front garden.
Cooper added: "Jacqui has attacked her. She clobbers her over the head with a big Santa Claus statue."
As Cindy is taken to hospital, Jacqui considers handing herself into the police, until Tony stops her and reveals how much she means to him with a kiss. However, whether the pair will actually get back together remains to be seen.
Jacqui and Cindy's showdown is one of several big Christmas storylines for Hollyoaks as the McQueens will also be rocked by the arrival of a mystery baby on their doorstep.
Meanwhile, tough times lie ahead for Brendan Brady (Emmett Scanlan) when his sister Cheryl tricks him into enduring lunch with his abusive father Seamus (pictured below right).
The Bradys are joined by Ste and Leah at the dinner, but an unsettled Brendan struggles to keep a lid on his emotions and ends up shouting at Leah.
The Osborne family will also feature heavily at Christmas as Nancy and Darren deal with the possibility that their baby son Oscar may be deaf.
Towards New Year, the family's troubles escalate as Nancy's nephew Charlie runs away and finds himself in danger.
Hollyoaks airs weeknights at 6.30pm on Channel 4, with first look screenings at 7pm on E4.