As reported yesterday, Fox's character Nancy Osborne will be left horrified at New Year as her young nephew runs away from home following an argument.
Viewers will see Charlie flee after a stressed-out Nancy loses her temper with him, feeling anxious and distracted after discovering that her baby son Oscar may be deaf.
Charlie heads out into the woods, but finds himself in danger when he trips and falls unconscious.
Fox told Inside Soap: "Nancy finds a heartbreaking note from Charlie which reads, 'I know that you don't want me any more'. Her first reaction is one of absolute panic, and the Osbornes all head off into the dead of night to try to track him down."
Fox said: "The two of them already have a fragile relationship. Frankie turns on Nancy and blames her for Charlie going missing - and if you push Nancy far enough, she'll bite back!"
Hollyoaks airs weeknights at 6.30pm on Channel 4, with first look screenings at 7pm on E4.