As shown on E4 last night (October 15) and Channel 4 this evening (October 16), evil Clare has been killed off after being run over by her enemy Doctor Browning.
Writing on Twitter, Bissix suggested that it is the right time for other villains to take centre stage in the soap.
Thank u for ur amazing support! Clare Devine is truly the BEST character I hav ever played!! It's bin n emotional ride!! xx— Gemma Bissix (@Gemma_Bissix) October 16, 2013
She said: "It's time to hang up the red stilettos and let some other villains cause some havoc."
Bissix played the role of Clare on and off from 2006, taking over from original actress Samantha Rowley in the part. She helped to establish Clare as one of the soap's most memorable characters.
In total, four deaths have now been confirmed in the 'Hollyoaks Blast' week as Doug Carter (PJ Brennan) and Ash Kane (Holly Weston) both died as a result of an explosion at the council flats, while Browning himself was killed by wife Mercedes after a terrifying showdown between the pair.
The fifth and final death will be revealed later this week. Fans have already seen Dodger Savage (Danny Mac) and Leanne Holiday (Jessica Forrest) rushed to hospital after being injured in the blast, leaving viewers to wonder which one of them won't make it through.
Hollyoaks airs weeknights at 6.30pm on Channel 4, with first look screenings at 7pm on E4.
Digital Spy Soap Scoop video - press play below to watch Amie Parker-Williams reveal gossip on an EastEnders murder plan, labour scenes in Hollyoaks, a proposal in Emmerdale and a big new feud in Coronation Street.