Fans can expect at least two shock deaths as a terrible chain of events leads to a mini-bus crashing into the wedding venue which is playing host to Tony Hutchinson, Cindy Longford, Ste Hay and Doug Carter's joint nuptials.
The drama begins when young couple Ruby Button (Anna Shaffer) and Martin 'Jono' Johnson (Dylan Llewellyn) decide to flee to Gretna Green to tie the knot. Although they would prefer a ceremony closer to home, eloping is their only option as they don't have the blessing of the Osbornes.
Bart McQueen (Jonny Clarke) is first choice to transport the pair and the other sixth formers to Scotland, but when he lets everyone down by getting stoned on the big day, it's time for a drastic plan B.
The gang are soon relieved when Maddie Morrison (Scarlett Bowman) spots a minibus with the engine running and hijacks it for all of them. As it's now or never to make sure the wedding goes ahead, the teens all jump on board and set off on their journey.
One of the only sixth formers not celebrating is Esther Bloom (Jazmine Franks), who is determined to stop the wedding. Tracking down Bart to help her, they set off after the mini-bus in hot pursuit.
As the two vehicles pass the joint venue for the other weddings, disaster strikes as Ste's daughter Leah steps out in front of the bus.
Maddie immediately tries to come to an abrupt stop, but to her horror, the brakes aren't working and she instead has to swerve to avoid Leah.
With the mini-bus now completely out of control, it ploughs straight into Ste and the wedding venue, causing a pillar to collapse and the roof to cave in. Not long afterwards, the crashed vehicle explodes…
Show bosses are keeping tight-lipped about which characters will meet their maker in the disaster, but after seeing a sneak peek of the episodes, Digital Spy can promise very emotional scenes ahead for some much-loved characters…
Hollyoaks airs these scenes on Wednesday, November 14 and Thursday, November 15 at 6.30pm on Channel 4.
> 'Hollyoaks' characters to die in crash horror
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> 'Hollyoaks' bus crash storyline gets spectacular new promo - watch
> Read more 'Hollyoaks' spoilers and news
Over on EastEnders, more rows are on the way for Christian Clarke and Syed Masood in the build-up to their departure from the show.
The pair have experienced more than their fair share of problems in recent weeks, but Syed (Marc Elliott) becomes determined to get their relationship back on track in upcoming episodes.
When Syed invites Christian (John Partridge) over for lunch in an attempt to patch things up, he is blissfully unaware that his estranged husband is actually planning to leave Walford and move to America.
Noticing how upbeat his son is, Masood is forced to break the news to a crushed Syed that Christian is leaving.
Later, when Syed sees Christian, he blasts him for keeping secrets and brands him a hypocrite. Throwing his belongings into the Square, Syed then declares that Christian leaving is best for everyone.
It's no secret that both characters will soon be bowing out, but will they be doing so together or separately?
EastEnders airs these scenes on Tuesday, November 13 at 7.30pm on BBC One.
> 'EastEnders' confirms Syed, Christian exits
> 'EastEnders' star Marc Elliott on exit: 'Three years was my limit'
> 'EastEnders' Marc Elliott: 'Syed does love Christian'
> 'EastEnders' John Partridge: 'Christian couldn't stay without Syed'
> Read more 'EastEnders' spoilers and news
Coming up on Coronation Street, Steve McDonald's insecurities get the better of him as he fears that girlfriend Michelle Connor will be wooed by Underworld colleague Rob Donovan.
Steve (Simon Gregson) becomes increasingly jealous of Rob later this month and even resorts to targeting him with a childish prank.
When Steve sees Rob (Marc Baylis) loading boxes on the back of Kirk's van outside the factory, he suddenly locks the doors on him and an oblivious Kirk sets off! This results in Rob losing out on an important order for Underworld as he misses a meeting.
Knowing exactly who is to blame, Rob later warns Steve that he'll get his revenge by stealing Michelle (Kym Lomas) from him. The ruthless businessman then invites Michelle on a work trip to Sheffield, leaving Steve fearful that Rob is about to make his move.
After the pair set off together, Steve approaches Eva (Catherine Tyldesley) and lets her know that something may be going on between Rob and Michelle. Teaming up, Steve and Eva then follow their respective partners, ready for a showdown.
When they arrive at the hotel in Sheffield, Eva convinces the receptionist to let her know which rooms Michelle and Rob are staying in. Soon afterwards, they hammer on Rob's door and find a scantily-clad woman inside his room.
To Steve's relief, the woman is not Michelle but in fact a young waitress, who swiftly leaves when a raging Eva reveals that she is Rob's girlfriend and exacts her revenge.
Steve wants to get away before Michelle learns that he suspected her of sleeping with Rob, but when she appears from her room, a devastated Eva blurts out the whole story. As Steve apologises for following her, how will Michelle react?
Coronation Street airs these scenes on Friday, November 16 at 8.30pm on ITV1.
> Read more 'Coronation Street' spoilers and news
Meanwhile, Emmerdale's Debbie Dingle will come face-to-face with Chas again later this month as she heads to the prison to demand answers.
Realising that she still can't make sense of Chas's devastating betrayal, Debbie (Charley Webb) decides to pay her a visit and finally hear her side of the story in full.
Chas (Lucy Pargeter) is nervous when Debbie arrives in the visitors' room, knowing that she can't make any excuses over her actions. Instead, she decides to just be honest - confessing that she genuinely loves Cameron.
As Debbie hears exactly what went on during the affair, it dawns on her that Chas is the one that Cameron loves, not her.
Debbie tries to cover her heartbreak, but deep down she is devastated as she still loves Cameron in spite of everything. With her love life in tatters and Sarah in hospital, will Debbie crumble?
Emmerdale airs these scenes on Thursday, November 15 at 7pm on ITV1.
> Read more 'Emmerdale' spoilers and news
Over on Doctors, the lines start to become blurred between Rob Hollins and DCI Driver as they pose as a couple for undercover work.
Pretending to be married in order to thwart a dangerous baby trafficker, Rob and Driver spend time together at their fake house in the hope that they can appear more convincing as husband and wife.
Once the working day is over, Rob (Chris Walker) seems reluctant to head home and instead suggests to Driver that they should work more on their backstory.
As Karen sits alone at home, Rob and Driver bond further over a bottle of wine and their attraction is evident…
Doctors airs these scenes on Monday, November 12 at 1.45pm on BBC One.
Hollyoaks topped our storyline poll last week as 35.8% of you chose Maxine's arrival as the best plot.
Emmerdale came second with 32.6% for Cain kissing Moira, while Coronation Street took third with 17.2% for Gloria's cheating being exposed.
EastEnders was fourth with 12.5% for Phil presenting Sharon with an engagement ring, while Doctors was fifth with 1.9% for Rob and Driver's big new case.
Don't forget to vote in the poll below to let us know which storyline sounds best this week!