Now working as editor of the Erinsborough News, Susan appears to be throwing herself into her career - but this could come at a cost to her health as she struggles with her MS again.
Digital Spy recently caught up with Jackie Woodburne, who plays Susan, to hear her take on the new chapter for her character.
"But I think this break-up's a bit different, because it's not about an affair - it's just that Susan's at a point in her life where she wants to see who she is if she's not a mother or a wife. Who is she as single Susan?"
Confirming that she has no plans to leave Neighbours, the actress added: "The show's going through a really strong phase at the moment. We've got a really great young cast, we've got a really, really good strong group of young actors at the moment.
"And that kind of reinvigorates those of us who've been in the show for a long time. We lock into their energy and their enthusiasm, and that inspires us - and in turn, hopefully we inspire them."
Neighbours airs weekdays at 1.45pm and 5.30pm on Channel 5 in the UK and weekdays at 6.30pm on Eleven in Australia.
Additional reporting by Daniel Kilkelly.
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