The decision to write the entire family out was made following the news that both Eloise Mignon and Steve Bastoni are planning to quit the series.
"I only planned to be on the show for a year to 18 months but I’ve been here two years now and have done enough," said Bastoni, who stars as patriarch Steve Parker. "There’s nowhere else for the character to go."
Mignon, who plays Bastoni’s on-screen daughter Bridget, quit the series to return to her university studies.
The Parkers will film their final scenes on Ramsay Street in April and leave Australian screens in July.