Writing on the soap's official website, Bower announced that the forthcoming special edition will feature a twist involving the Ramsay Street villain, marking the long history that his portrayer Stefan Dennis has had with the programme.
The show boss explained: "Last week I saw episode 6,000. This marks Australian television history. The 6,000th episode falls on a Friday so the whole week is a special one.
"As Stefan Dennis - Paul Robinson - was in the first episode 25 years ago, it was decided that his character play a most important role in this very special event.
"Paul Robinson, or P.R as we like to call him, has been up to his usual tricks over the past few weeks and everyone on Ramsay Street is becoming really sick of him. What will they do about it?"
Bower had previously hinted at a storyline involving Paul for the 6,000th episode, but had not officially confirmed the plot until now. Additionally, Alan Fletcher - who plays Karl Kennedy - has teased that the instalment sees "something rather unpleasant" happen to an iconic character.
Neighbours' 6,000th edition will also see on-off lovers Ringo Brown (Sam Clark) and Donna Freedman (Margot Robbie) tie the knot.