The actor, who quit his role as Geoff Campbell in Home and Away in 2009, will join Ramsay Street for a four-week stint.
In scenes to be filmed in Port Douglas, Northern Queensland, Lewis will play a marine biologist who encounters some Erinsborough locals including Kate Ramsay - played by Ashleigh Brewer.
Kate is on a mission to escape the drama of Erinsborough when she meets Lewis's charismatic character Dominic Emmerson and finds him to be the distraction she has been looking for.
"I've wanted to be on Neighbours since I was a little kid and finally it has happened," Lincoln said. "I'm filming in Port Douglas and working with Ashleigh Brewer and Stefan Dennis, it doesn't get any better."
Lewis and Brewer have previously worked together in children's series The Sleepover Club when they were aged 12.
Lewis is currently starring in Australian television mini-series Underbelly: Razor.
> Home and Away star leaves Sydney after soap exit