Carmel, played by actress Kirsty Child, will pay a surprise visit to Susan later this year - before sticking around in Erinsborough for a two-month stint.
Pictured: Kirsty Child as Carmel Tyler.
Neighbours fans were originally introduced to Carmel in 2002, when she helped to track down Susan after the popular character had gone missing while suffering from amnesia.
This time around, viewers can expect to see Susan and Carmel's relationship tested as their strong personalities lead to some clashes. Things later become even more complicated when they both fall for the same man.
Child, confirming her return, commented: "It's been great fun to be back and wonderful to work with some familiar faces, and also lots of new and very talented young actors."
Carmel's return scenes air in November in Australia and a month later for UK audiences.