The pair's characters Paul Robinson and Ajay Kapoor will come to blows in a forthcoming episode of the soap, as the tension between them reaches boiling point.
Pictured: Sachin Joab and Stefan Dennis on set at Neighbours.
Paul and Ajay have struggled to get along for quite some time. However, the show's team are currently keeping tight-lipped over exactly what leads to their violent clash - and who throws the first punch.
Dennis commented: "Ahh, you'll have to watch and see. However, I can say that any after-effects were applied by the make-up department, which we were both very pleased about.
"I think if Sachin punched me for real, I'd be back in a coma - he is a pretty fit guy!"
Dennis confessed that Neighbours fight scenes were not choreographed so professionally during his early years at the soap.
He commented: "I remember doing a scene with Alan Dale, who played my father back in the '80s. He had to slap me, and we felt the only way it was going to look real was if he actually hit me.
"He ended up belting me about eight times. I had swollen cheeks by the end of the scene and Al just felt terrible."
Upcoming Neighbours episodes will see Paul pursuing Ajay's wife Priya, leaving her struggling to resist his advances.
Neighbours airs weekdays at 1.45pm and 5.30pm on Channel 5 in the UK, and weekdays at 6.30pm on Eleven in Australia. Get the Inside Soap magazine on your iPhone or iPad