The show regular, played by Christopher Milligan, makes the tough decision after realising that he cannot settle for a long-distance romance.
Ramsay Street's latest love split occurs after Jade returns home early from another work trip to Los Angeles.
As Jade reveals that she has been asked to relocate to the US for a year, Kyle is left reeling by the bombshell and calls time on their partnership - making it clear that his future is in Erinsborough.
TV Week quotes Kyle as saying: "What if one year turns into two? If they ask you to stay for longer, what will you say? You want LA, I want us. It's just not going to work."
The break-up comes just before Jade departs Ramsay Street for good. Gemma Pranita, who played the personal trainer, filmed her final scenes in August.
Neighbours airs Kyle and Jade's break-up next week on Eleven in Australia, and in November on Channel 5 in the UK.