Steph Scully (Carla Bonner) will be making a welcome return, as well as Sarah Beaumont (Nicola Charles) and Detective Mark Brennan (Scott McGregor).
Lou Carpenter's daughter Lauren Turner (now played by Kate Kendall) will also be coming back, but she will joined by her family to form a new set of characters in Erinsborough.
On joining the long-running soap, which will celebrate its 28th year in 2013, Kendall said: "It's exciting to be joining Australia's longest running drama and to be working with such an array of experienced actors.
"To be playing a character such as Lauren Turner, who is deeply embedded in the storyline and who of course is Lou Carpenter's daughter, is such a wonderful opportunity."
Lauren will be joined by police sergeant Matt Turner (Josef Brown) and their teenage children Mason (Taylor Glockner), Amber (Jenna Rosenow) and Bailey (Calen MacKenzie).
Rick Maier, executive producer of drama and production at Australian broadcaster Network Ten, added: "Neighbours is always as its most compelling when fans are rewarded for their commitment. Next year's new stories and all-star cast just look and feel fantastic. Steph Scully back on Ramsay Street? Sarah Beaumont? And some people thought Erinsborough was such a quiet place to live...
"We are thrilled that they are returning to Ramsay Street and equally excited to be introducing a new family with original ties to the neighbourhood." Get the Inside Soap magazine on your iPhone or iPad