Earlier today (November 26), the long-running show announced that Ben Barber, Jordan Smith and Kaiya Jones - who play Rhys Lawson, Andrew Robinson and Sophie Ramsay respectively - will all depart screens next year.
Storyliners apparently have "heartbreak and triumphs" lined up for the trio's exit plots, which are currently being kept under wraps.
Executive producer Jasek (pictured above right) said in a statement: "All the characters departing will leave a legacy on Ramsay Street which is testament to the extraordinary talents of the actors playing them. Communities are constantly changing and Neighbours is reflective of this.
"2013 will be an extraordinary year of revelations and dynamic story arcs which unfold at a cracking pace, and we look forward to taking viewers on this rollercoaster."
Nicola Charles (Sarah Beaumont), Carla Bonner (Steph Scully) and Scott McGregor (Mark Brennan) will all be returning to screens as guests next year, while the new Turner family regulars have been tipped to arrive "under a shroud of secrecy".
Neighbours airs weekdays at 1.45pm and 5.30pm on Channel 5 in the UK, and weekdays at 6.30pm on Eleven in Australia. Get the Inside Soap magazine on your iPhone or iPad