The Willis clan will descend on Ramsay Street in the middle of the year, with former Home and Away stars Kip Gamblin and Rebekah Elmaloglou taking on the roles of married couple Brad and Terese.
Brad and Terese will be joined in Erinsborough by their teenage son and daughter. Fans will already be familiar with Brad as he previously lived on the street in the early '90s, when Scott Michaelson played the part.
Today's news follows the recent decision to bring in the Turner family, headed up by Lou Carpenter's daughter Lauren.
Neighbours' executive producer Richard Jasek commented: "We are moving our focus back to family units on Ramsay Street, and the dynamics this offers in terms of storylines is fantastic.
"As viewers will find out shortly, the Turners are a family of secrets, and the unique backstory of the Willis family is just as compelling."
Gamblin and Elmaloglou are known to soap fans for their respective roles as Summer Bay's Scott Hunter and Sophie Simpson.
Neighbours' new recruits will start filming in two weeks' time, debuting on screen in early June in Australia and three weeks later in the UK.
New! Digital Spy Soap Scoop video - watch Amie Parker-Williams reveal the biggest storylines on the way in Coronation Street, EastEnders, Emmerdale and Hollyoaks next week.