Fans in the UK and Australia are being invited to take part in an Ashes-style contest titled 'Neighbours Remixed', which will see the theme music get a revamp later this year.
Participants will enter by recording and uploading their own voice singing the newly-updated Neighbours theme.
Five finalists from the UK will later be shortlisted and then viewers will be asked to pick a winning representative, who will fly to Melbourne and face a head-to-head sing-off with the successful Australian representative.
The overall winner will become the vocalist on a remixed version of the Neighbours theme tune, which will air on the opening credits around the world from April 15.
Greg Barnett, Channel 5's Commissioning Editor for Entertainment, Daytime and Soaps, commented: "We've beaten the Aussies in the last two cricket meetings, so I'm confident a UK soloist can be crowned the voice of the new Neighbours theme.
"We're using Soundcloud as our mode of entry, so it's super-accessible and the prize is absolutely fantastic. The UK has an amazing pool of talent so I'm truly confident this is a prize we can win."
All five UK finalists will hear their recordings of the Neighbours theme played over the show's opening titles on Channel 5 during the week of March 18.
Once all five have been broadcast, viewers will be invited to vote for their favourite in an online poll, and the winning choice will head down under for a sing-off against the Australian contender.
The minimum age for entry is 18 and the closing date for entries is midday on Friday, March 1. Full details on how to enter can be found on the 'Neighbours Remixed' website.
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