The actress, who appeared on screen as schoolgirl Rani Kapoor from early 2012, had her final day on set yesterday (April 30).
After saying goodbye to cast and crew, Cherian tweeted: "Just got so spoilt by the most incredible bunch of people in the world! I love you all so very much and miss you already."
Neighbours' executive producer Richard Jasek told Digital Spy: "It's very special when someone joins the Neighbours family as a youngster and then to have the privilege of watching them grow into an extraordinary young adult.
"We have all adored working with Coco and like all our characters, we hope there will be an opportunity with our stories for Rani to make a return visit to Ramsay Street.
"In the meantime, we wish her all the best in the future."
Menik Gooneratne, who played Rani's mother Priya, also left Neighbours earlier this year as her character was killed off in Toadie and Sonya's wedding day explosion.
Additionally, the departure of Sachin Joab - who played Rani's father Ajay - was confirmed in March.
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