The 21-year-old actor - who played Geoff Campbell in the show - will film his final scenes with the series on Friday, before starting work on his next project, the film adaptation of best-selling teen novel Tomorrow: When The War Began alongside former Neighbours star Caitlin Stasey.
"I've been working in the training for the film with my commitments on Home and Away, so it’s been pretty busy," Lewis said.
"It's sad to be leaving the cast and crew on Home and Away. It was a hard decision to make, but I also think it’s the right time to go."
In July, Channel Seven denied rumours that Lewis was to leave the soap after he admitted to his role in a sex tape scandal.