The 32-year-old has left the soap in order to try and launch a career in Hollywood next year, Australian paper The Telegraph reports.
It is not yet known how Anderson will depart the soap, though her exit is tipped to tie in with Charlie's romance with River Boy Brax (Steve Peacocke).
Home and Away producer Cameron Welsh refused to be drawn into speculation over Anderson's future, writing on Twitter: "Sorry folks, haven't seen the paper and I don't comment on cast rumours."
Anderson has been involved in several major storylines since joining the cast in 2008, including a controversial lesbian relationship between Charlie and Joey Collins (Kate Bell) in 2009.
Anderson recently denied rumours that she is dating Peacocke in real life.