The 56-year-old - who battled the Time Lord as an evil Slitheen in 2005 - is to play Sarah Hardy, a cantankerous woman who feels persecuted by her noisy neighbours and their new-born baby.
Usually-calm and collected, Sarah decides to fight back in order to protect the delicate balance of her lonely life. And it’s Senior Practice Nurse Michelle Corrigan (Donnaleigh Bailey) who helps Sarah realise that her neighbours could actually do with some friendly support since the death of their eldest child.
Speaking of her role, Annette told DS: "Being a Brummie, it's so lovely filming back home, especially since it means I don't have to put on a different accent! I'm having a wonderful time on the Doctors set; the cast and crew are all lovely and it's a real laugh shooting my scenes with fellow Brummie Donnaleigh.
"Sarah is such a fantastic character to play because she's so complex and not terribly pleasant - not quite a Slitheen but not far off either!"
Producer Natasha Carlish commented: "We are all very excited about having Annette on the show. The character of Sarah has required Annette to play her with a tough exterior and an inner vulnerability so that the viewer can ultimately feel sympathy for her plight. Annette has delivered just that and more."
She added: "Annette has been a real delight to work with; charming and gracious even on a typically hectic Doctors schedule! We all feel very privileged to have the opportunity to work with her and I am sure that the episode will provide great viewing for our audience."
Annette began filming in Birmingham last week and her episode is due to transmit on Tuesday, November 6.