Nicolas Woodman, who plays Jack Hollins, makes his final appearance on the soap on Friday, September 21. The actor's on-screen sister Charlie Clemmow (Imogen) then leaves in the following episode on Monday, September 24.
The news probably won't be a huge surprise as our recent Doctors producer interview hinted at a possible "empty nest" for Rob and Karen, while there has been speculation among viewers over Jack and Imogen's future for a few weeks.
Charlie has already confirmed her next project, playing the role of Ela in the play Charley's Aunt at the Menier Chocolate Factory in London. The production opens later this month.
Meanwhile, Janet Dibley's character Elaine will also be leaving on September 24 in the conclusion to Harrison's return storyline.
Doctors airs weekdays at 1.45pm on BBC One.
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