The first episode will premiere on E4 on Monday, September 17.
The programme will then air nightly on E4 at 10pm for five episodes from September 17 to September 21, with each edition running for an hour.
Brendan Brady (Emmett Scanlan) will play a starring role in the series, which takes advantage of the post-watershed slot to produce a darker, more risqué programme.
Commissioning editor for Channel 4 Marianne Buckland said: "This series of Hollyoaks Later represents the next turn of the wheel for the brand and promises a glossier, more grown-up feel.
"By their very nature, the lateness of Laters allows us to be that little bit more risky and with Brendan Brady at the helm - a character so suited to a post-watershed stint - this year is more dark and dangerous than ever."