Catch up here if you missed part one of our chat, or read on for the latest teasers…
Would you bring back any faces from Holby City's past?
"There are no immediate plans to bring anybody back as a full-time regular, although it's certainly not something that I'd rule out. What I can promise for the upcoming months is that you can certainly expect a sprinkling of returning faces here and there."
Are there any other new regulars joining who we haven't heard about yet?
"I can tell you exclusively that we've just signed the actress Wendy Kweh and she will play the wife of Joe McFadden's character Raf. She will be on AAU as a consultant pharmacist and she will be at the centre of a very explosive storyline."
What's coming up for Serena and Edward?
"I think it's pretty clear from what we've seen on screen that Edward is a bit of a wrong'un. Serena pretends to hate Edward, but he's very much her Achilles heel and it's a bit like somebody walking deliberately into the path of an oncoming train, so I can promise it will not be pretty."
Does Michael have some bigger stories ahead?
"Michael has been a bit quiet but in the upcoming weeks, we will see the aftermath of Chrissie going. He thought that he'd found the potential love of his life there, but now he's lost her. Also, let's just say we'll also see tensions between him and Sacha come to a head due to Sacha having found that letter in Chrissie's leaving episode."
What's coming up for Mo?
"Mo is very much present in the pregnancy story as she finds herself increasingly caught between Jonny and Jac, which gives her a lot of grief. The major curveball we throw at her is when her sister Adele arrives at the hospital. What's really nice about it is that, on paper, Mo is the sister who's done better and come good - but Adele has a wonderful talent of making them feel like children again. That makes Mo feel slightly undermined, so there's that to watch out for.
"As time goes on, Mo does start to question herself professionally and her place in the hospital - but I can assure the fans that she's not leaving the show."
A few of our readers were keen to know if you'd ever promote Ben Hull to a regular cast member.
"Well, we know that the chemistry between Mo and Ben's character is something that we need to resolve one way or the other. 'Will they, won't they?' stories - like Jac and Jonny's - are sometimes so delicious that you don't ever want to quite resolve them, but we will be doing something with it one way or another.
"As for Ben as a regular, it would be lovely but we do have our three wards and Mr Thompson isn't one of the personnel on those wards as he's a gynaecologist obstetrician. It's such a treat when Mr T comes to visit, whether as pertinent to Mo's story or when we feature baby stories, but I can promise that you will keep seeing him."
Can you tell us what's ahead for Harry once Gemma leaves?
"What's great about Harry on his own is that it takes him back to his bad boy roots. I think people love Harry because he has charm, but he's ultimately arrogant, self-interested and funny. We'll see him go back to that as he always wants to get ahead in his career, and serve those interests by fair means or foul. He's having a lot of fun doing that at the moment!"
Will there be a new direction for Arthur with Chantelle gone?
"The Holby landscape is completely transformed for Arthur. Chantelle is gone and he's a bit confused by Zosia. What's interesting about Arthur and his stories now is that they completely change. Rob [Ostlere] is such a talented actor and he's really getting his teeth into it. Arthur used to be the sole junior star doctor and was mentored by Malick and Hanssen. Suddenly with those two gone, he's not the spoiled child of the hospital anymore.
"With Zosia and Dominic in the picture, Arthur doesn't really like it and he feels that he has to fight for his place more. His world is also totally rocked by the return of Dominic, who he absolutely hates. There'll be a big rivalry there…"
How about Mary-Claire?
"I love Mary-Claire and I think Niamh [McGrady] is a brilliant actress. She brings charm, warmth and comedy to the show. People will have seen Mary-Claire and Edward drawn together slightly. She's stuck in a cycle of going for the wrong men, and the situation with her, Edward and Serena is not going to be pretty. What's lovely is that with Colette coming in, she has a boss figure who will fight her corner and stand up for her.
"With Mo's sister Adele also joining the show, there's also a lovely friendship dynamic between her and Mary-Claire with lots of fun and banter. In some ways it reminds me a lot of the Donna and Maria era which many viewers might remember."
Can you tell us about future plans for Elliot?
"Elliot's world is really rocked by the arrival of yet another new boss - that always really unnerves him. There's a big upcoming story where he feels very much under the scrutiny of Guy and it makes him question his ethics and his professionalism. We'll also see him being a great source of support and wisdom for Jonny and Jac throughout the pregnancy. The Jac and Elliot relationship is something I particularly love and cherish. Often they'll be at odds professionally because they have such different approaches, but there are also lovely windows of tenderness and care between them.
"Without wanting to give too much away, there'll also be a really big story for Elliot in 2014..."
> 'Holby City' gossip and teasers from producer Simon Harper - part one
> Read more 'Holby City' spoilers and news
Holby City airs Tuesdays at 8pm on BBC One.
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