The actress's character Daisha Anderson will be seen on screen for the final time later this month after a brush with death makes her realise that she wants to return home to the Philippines. Grant has already filmed her final scenes with the medical drama.
Paying tribute to her Holby colleagues, she commented: "It has been the most wonderful two years of my acting career. I'm grateful to the producers for throwing me into the deep end by giving me some of the toughest storylines to work on.
"All the actors have been great, they have been a dream to work with and [they] have given me the courage to pursue my acting career in the States."
Grant was first seen on Holby City in March 2008 and her alter ego Daisha quickly became known for her straight-talking nature.
Daisha will appear for the final time on the programme on March 23.