The 44-year-old, who starred in Emmerdale and Holby City, is mother to sons James and Lennon from her marriages to Jim Kerr and Liam Gallagher.
Kensit, who quit Holby in 2010, told PA: "I never say never. Who knows when the boys have grown up and left home? Something like that would be amazing again, but right now I need something a little bit different, I think."
However, the actress insisted that her "relentless" stints took their toll on the quality of her family life, saying: "There's a lot to be said for working flat-out for four months and having no life and having to juggle everything with your family, your children, after-school things you're meant to be at. Four months out of the year you can get round that.
"Week in, week out, year in, year out, it's really tough. Two and a half [years] on Emmerdale, four and a half [ years] on Holby, and when I left Holby I realised my eldest son was a man.
"I'd been very hands-on; I'd been there obviously, but it was such a shock to me. I got rid of any childcare help I had. I thought, 'I'm going to be a full-time mum now'. I need to work. I can't just do the school run and cook for the rest of my life, but I've got to find a job that can fit into family life as well."
Shortly after leaving her role as Faye Morton on Holby City, Kensit admitted that she felt exhausted by the commitment.
> Patsy Kensit: 'I'm going to be a granny'
> Patsy Kensit: 'I will never marry again'