The actress's emotional final scenes aired this evening (October 23) as Eddi left the hospital for the last time, bowing out to overcome her addiction demons.
Viewers saw former Emmerdale star Luke Tittensor reprise his role as Eddi's brother Liam for the farewell episode.
As show bosses did not reveal Eddi's departure ahead of tonight's edition, fans will have been surprised by the top-secret storyline conclusion.
Speaking of her Holby City exit, Potts exclusively told Digital Spy: "I am proud that I have been a part of this fantastic programme and I'm really thankful that I have had the opportunity to work on this show.
"I'd never say never to coming back - I absolutely love the programme and all the people at Holby."
Eddi's romantic pairing with Luc Hemingway (Joseph Millson) proved particularly popular with viewers, resulting in a vocal fanbase of 'Team Leddi' supporters.
Holby City's consultant series producer Justin Young added: "We were very sad to say goodbye to Sarah-Jane, but we always agreed that Eddi would only be a part of the Holby team for a limited time.
"In just a year, Sarah-Jane created a fantastic character, and - along with Luc - became half of one of the most talked about couples in Holby's history.
"Sarah-Jane was great to work with and we miss her. It's the end of Luc and Eddi's story for now, but who knows what the future might hold?"
Since filming her final Holby City episode, Potts has moved to the USA with her partner and son.