The actor, best known for playing Weatherfield butcher Fred Elliott, will appear on the BBC One medical drama at Christmas.
Savident has taken on the part of Rupert Popol, a well-spoken older gentleman who turns up at the hospital following a road accident.
Rupert has managed to run someone over on the road, but has no memory of what he has done.
Pictured: John Savident in Holby City.
Viewers will see Savident share most of his screen time with Bob Barrett, who plays Sacha Levy.
Savident portrayed the role of Fred on Corrie from 1994 until 2006, when the popular character - well-remembered for his "I say" catchphrase - suffered a fatal heart attack. The 74-year-old has since concentrated on stage work.
Holby City airs on Tuesdays at 8pm on BBC One.