Residents of both Albert Square and Weatherfield will find themselves coming face-to-face with each other in the charity special. The crossover comes in the year both soaps celebrate significant anniversaries.
EastEnders cast members confirmed to be involved include: John Partridge (Christian Clarke), Laurie Brett (Jane Beale), Nina Wadia (Zainab Masood), Charlie G. Hawkins (Darren Miller) and Kylie Babbington (Jodie Gold). Stars of Coronation Street taking part are: Sue Cleaver (Eileen Grimshaw), Antony Cotton (Sean Tully), Julie Hesmondhalgh (Hayley Cropper) and Shobna Gulati (Sunita Alahan).
Check out some pictures of the two soaps' casts colliding for the very first time!
Cotton recently teased fans of the special when he posted a picture of himself and Partridge on Twitter.
No details about the plot have been revealed.
Children In Need takes place on Friday November 19 from 7pm on BBC One.