The BBC drama beat off competition from Coronation Street, Emmerdale and Hollyoaks to be named 'Best Soap', while show favourites Jessie Wallace and Shane Richie also secured gongs.
Wallace, who plays Kat Moon, triumphed over Emmerdale star Pauline Quirke and Coronation Street's Katherine Kelly and Michelle Keegan in the 'Best Soap Actress' category.
Meanwhile, her screen husband Richie (Alfie Moon) won the 'Best Soap Actor' prize. Coronation Street's Simon Gregson, Emmerdale's Danny Miller and Hollyoaks' Emmett Scanlan had also been nominated in the category.
Coronation Street also secured recognition as the 50th anniversary tram crash disaster was voted the 'Best Soap Storyline'.
Additionally, Weatherfield's new recruit Paula Lane (Kylie Platt) was named 'Best Soap Newcomer'.
The TV Choice Awards 2011 were hosted by Ben Miller and took place tonight at a ceremony in London.
> Look back at the full soap nominations list for the TV Choice Awards 2011
> Read more EastEnders spoilers and news
> Read more Coronation Street spoilers and news