Simon May, who composed the original EastEnders theme in 1984, has reworked the tune to create 'Pat's Theme' - which will play out at the end of the Albert Square legend's last episode.
EastEnders bids a heartbreaking farewell to Pat on New Year's Day following her recent diagnosis of terminal cancer.
In real life, meanwhile, Pam St Clement has decided to bow out from EastEnders to pursue other work and life opportunities.
EastEnders fans will already be familiar with the show's long-standing alternative tune 'Julia's Theme', which traditionally airs at the end of episodes featuring intense emotion or drama.
Peggy Mitchell, played by Barbara Windsor, also had her own version called 'Peggy's Theme' when she departed Walford in September 2010.
The New Year's Day episode of EastEnders will also feature an updated opening title sequence, as the Olympic Park will be included in the graphics for the first time. The sporting complex will play host to the Summer Olympics and Paralympics in 2012.
An EastEnders insider told Digital Spy: "It's only right that as we say goodbye to the iconic Pat Evans we pay tribute to such a character with a wonderfully touching special theme tune.
"As we say farewell to a legend of over 26 years, we welcome in what will be a truly remarkable New Year in E20 by adding the Olympic Park into the opening title sequence."
EastEnders airs a 70-minute-long episode on New Year's Day from 7pm.
> EastEnders: Pat Evans's final moments in pictures
> EastEnders: Pat says goodbye to David and Janine - Unseen Pictures
> EastEnders star Pam St Clement on bowing out as Pat
> Read more EastEnders spoilers and news