The shop manager, played by Matt Lapinskas, will depart screens in the coming weeks after less than a year in Walford.
Lapinskas, confirming his exit, commented: "I'm having a fantastic time working on EastEnders and playing the role of Anthony Moon. Working with David Essex, Tony Discipline and the EastEnders cast has been an absolute pleasure.
"Although I will really miss EastEnders and everyone involved, I am very excited about future projects and what is next for me as an actor."
Anthony turned up on Albert Square last July, just a few weeks after his dad Eddie and brother Tyler.
His storylines have included short-lived romances with Poppy Meadow and Amira Shah, as well as a dangerous encounter with the villainous Derek Branning.