The actress's character Rose Cotton will bow out on screen later this year.
Speculation over Perkins's Albert Square future began a few days ago when show favourite June Brown, who plays Dot Branning, hinted that Rose would be leaving in a newspaper interview.
An EastEnders spokesperson told Digital Spy today (May 18): "Polly Perkins will be departing EastEnders later this year, however there is always scope for her to return in the future."
EastEnders bosses announced the casting of Perkins as Dot's half-sister in May last year and the character arrived on screen in August.
Fans saw Dot track her sibling down in Southend, before Rose decided to move to Walford.
June Brown, meanwhile, is currently on a break from EastEnders, but her agent has assured viewers that the 85-year-old intends to return "in the not-too-distant future".