Fans know that Derek will lose his life at Christmas, but show bosses have kept tight-lipped over whether a murder, suicide, accident or natural causes will lead to his passing.
Bookmaker William Hill has now made Derek (Jamie Foreman) the 9/2 favourite in its 'Who killed Derek?' betting, believing that the bad boy taking his own life is the most likely outcome.
William Hill spokesman Joe Crilly commented: "There are a number of storylines unravelling in which Derek could be involved, and it may all get too much on Christmas Day."
Lauren Branning (Jacqueline Jossa) is currently second favourite to kill Derek with odds of 5/1, after a recent storyline saw the schemer plot to break up her relationship with Joey.
Other potential culprits include Tanya (6/1), Alfie (7/1) and Max (8/1).
Alfie (Shane Richie) will naturally hold a grudge against Derek if he turns out to be Kat's mystery lover when the truth is revealed next week.
Meanwhile, Derek will also cause chaos for Tanya (Jo Joyner) and Max (Jake Wood) over the festive period by sabotaging their wedding plans.
Crilly added: "It is thought that Derek will be largely involved in the current storylines surrounding Alfie and Kat, as well as those involving Max and Tanya, and there will certainly be a number of suspects when Derek is offed."
EastEnders continues tomorrow (December 13) at 7.30pm on BBC One. Get the Inside Soap magazine on your iPhone or iPad