EastEnders claimed the title of 'Best Soap' for the second year running, pulling ahead of the six other nominees with 32.4% of the votes.
The Walford drama's nearest rivals were Corrie with 22.7%, Hollyoaks with 20.0% and Emmerdale with 11.2%.
Meanwhile, EastEnders star and I'm a Celebrity, Get Me Out of Here! winner Charlie Brooks was voted 'Best Female Soap Actor' for her portrayal of Janine Butcher, taking 23% of the overall votes.
Brooks was followed by Coronation Street's Michelle Keegan (Tina McIntyre) in second place with 14.2%, while Hollyoaks' Claire Cooper (Jacqui McQueen) was third with 13.7%.
Speaking of EastEnders' double success, executive producer Lorraine Newman told Digital Spy: "We are absolutely delighted with our two DS awards: 'Best Soap' and 'Best Actress' for Charlie Brooks, and a huge thank you goes out from the team here at EastEnders to all the DS readers who voted for us. The most precious awards of all are those which are voted for by our viewers.
"In Janine, Charlie has created the most manipulative, deliciously mischievous villain, someone who our writers delight in portraying and the audience adore. We wish the DS team and all their readers a magical, soap-explosive Christmas."
Coronation Street triumphed with the 'Best Storyline' of the year as Tyrone and Kirsty's dark tale of domestic violence proved most popular in the voting.
The ongoing plot saw off competition from Heather Trott's murder in EastEnders (2nd place), the wedding day bus crash in Hollyoaks (3rd place) and the huge drama surrounding Chas Dingle and Cameron's Murray's affair in Emmerdale (4th place).
Natalie Gumede, who plays unstable Kirsty, told Digital Spy: "The domestic violence storyline has been a challenging one, but made all the more rewarding by the heartfelt support of the fans who have reached out online. Thank you to everyone who voted."
Hollyoaks favourite Emmett Scanlan, better known as bad boy Brendan Brady, was the final winner in the soap voting as he secured the 'Best Male Soap Actor' title.
His nearest competitors were Coronation Street's Alan Halsall (Tyrone Dobbs) in second place and EastEnders' Jake Wood (Max Branning) in third.
Thanking Digital Spy readers, Scanlan commented: "At no point does news like this ever cease to shock me. I am truly honoured that you guys have seen fit to vote for me, hell, even Brendan Brady is honoured… well to be honest he doesn't care, but deep down I can tell it matters.
"You guys are the driving force behind every show, every actor, and every decision. Thank you for accepting this rough, whiskey riddled looking Irishman into your homes with open arms. I'm forever indebted to you for the kindness you have shown me over the years. God bless and much love."
The top 5 rankings for the soaps categories in the Digital Spy end of year poll in full are as follows:
1. EastEnders - 32.4%
2. Coronation Street - 22.7%
3. Hollyoaks - 20.0%
4. Emmerdale - 11.2%
5. Neighbours - 5.6%
Best Male Soap Actor
1. Emmett Scanlan (Brendan Brady, Hollyoaks) - 22.0%
2. Alan Halsall (Tyrone Dobbs, Coronation Street) - 18.2%
3. Jake Wood (Max Branning, EastEnders) - 15.2%
4. Steve McFadden (Phil Mitchell, EastEnders) - 10.7%
5. Tom Lister (Carl King, Emmerdale) - 7.0%
Best Female Soap Actor
1. Charlie Brooks (Janine Butcher, EastEnders) - 23.0%
2. Michelle Keegan (Tina McIntyre, Coronation Street) 14.2%
3. Claire Cooper (Jacqui McQueen, Hollyoaks) - 13.7%
4. Jo Joyner (Tanya Cross, EastEnders) - 13.4%
5. Alison King (Carla Connor, Coronation Street) - 9.7%
1. Tyrone and Kirsty's domestic violence (Coronation Street) - 28.3%
2. Heather's murder (EastEnders) - 25.9%
3. The wedding day bus crash (Hollyoaks) - 25.0%
4. Chas and Cameron's affair rocks Debbie and Dan (Emmerdale) - 8.9%
5. The teens' car crash (Neighbours) - 5.5%
More than 25,000 votes were registered in Digital Spy's end of year reader poll, held to decide the ultimate in entertainment and tech from the last 12 months. Get the Inside Soap magazine on your iPhone or iPad