Ayesha departed Albert Square earlier this week, but viewers have not seen the last of her as she arrives back on February 21 and makes another attempt to woo Masood.
Speaking on This Morning today (February 8), Ganatra kept tight-lipped over how Masood will respond to Ayesha's latest advances.
Ganatra teased: "I think she will return and put Masood on the spot again. She may even offer herself up again. What's a man to do?"
He continued: "I get a lot of pats on the back at the moment from the guys, and a lot of, 'So? Will you, won't you?'"
Ayesha's return will come after Masood's long-time partner Zainab (Nina Wadia) has left Walford for good.
The pair's 30-year relationship has hit crisis point this week, and tonight's episode sees Zainab make her final appearance on the Square.
Ganatra said: "It's been really beautifully written. They're very well-crafted episodes, and they've been directed beautifully as well. For Nina and I, it was a real joy, because you could actually breathe in a scene. In last night's episodes, there were moments of silence."
He added: "It was very emotional doing those. Nina and I have known each other for a very, very long time. We've been playing husband and wife for five years and we have a really good rapport.
"We have shortcuts, and we're very quick at throwing ideas at each other. So these scenes were really emotional for everyone."
EastEnders airs Zainab's final episode tonight (February 8) at 8pm on BBC One.
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