The actor will return to filming in February in his role as Deano Wicks, the estranged son of Shirley Carter (Linda Henry).
Deano last appeared on screen in February 2008, when he left Walford after experiencing a tough time in prison.
Shirley currently believes that her son is working in a bar in Australia. However, she will be shocked later this year when her father Stan (Timothy West) informs her that Deano is now going by the name of Dean and is much closer to home.
Speaking of his EastEnders return, Di Angelo commented: "It's such an exciting time for the show and the Carter/Wicks family that I just couldn't pass up the opportunity to reprise the role of Dean! I'm looking forward to getting back on the Square."
EastEnders' executive producer Dominic Treadwell-Collins added: "Matt is a gorgeous, charming, talented actor and it's fantastic that he's agreed to come back to the Square. Deano left angry with his mother. The Dean who returns is angrier. Shirley has been secretly hoping for her son's return. Let's hope she doesn't regret that."
Di Angelo has starred in a number of TV dramas since leaving EastEnders, including Hustle, Borgia and Death in Paradise.
EastEnders is airing every night on BBC One this week, including an extra Wednesday episode tonight (January 15) at 8pm.
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