Kazinksy – who first appeared as Albert Square's Sean Slater in August last year – has reportedly been taken on by Brad Pitt's agent who has high hopes for him in Hollywood.
A source told The Sun: "He's desperate to be a Hollywood star. He's ambitious, which Americans love, and easy on the eye – the first thing that Hollywood producers look at."
The 24-year-old actor will remain filming at the soap's Borehamwood home until October, continuing on-screen until the end of the year. The fate of his character has yet to be decided.
A spokeswoman for the soap today said: "EastEnders can confirm that Rob Kazinsky will be leaving later this year. We wish him all the best for the future."
Rob Kazinsky added: "If I had done everything I wanted to do as an actor before I joined EastEnders I would have wanted to stay forever. I have really enjoyed my time with the show - it's such a wonderful place to work and it's become more like a second home to me. I'll be sad to leave."
Of his exit, a BBC spokeswoman said: "As the character did not have any big plots coming up it was agreed Mohammed would leave. He is in talks with the BBC about other projects."
Both actors were suspended from the show for two months in the early part of last year – Kazinsky for sending lewd text messages to a model and George over suspicion of causing actual bodily harm to partner Emma Archibald.