The trek to Bucharest will see Sam Nixon (Lisa Maxwell) and Phil Hunter (Scott Maslen) investigating an influx of human trafficking.
A spokesperson for the show told DS: "We’re extremely excited about taking The Bill to Romania to shoot a two-part special.
"The episodes will be following DS Sam Nixon and DS Phil Hunter on an undercover mission to expose a human trafficking operation and will be crammed with action and stunts.
"It’s a fantastic opportunity for all involved and we’re particularly looking forward to collaborating with a Romanian film crew and filming out on the streets of Bucharest."
This is the third time the show has been overseas to film special episodes, travelling to France in 1999 for a murder investigation and, more recently, Australia, for the 'Beech on the Run' episodes starring Billy Murray in 2001.
The Romania special will air in September.