Current Weatherfield star Katherine Kelly (Becky Granger) recently claimed that Jones was hoping to reprise her role as Karen McDonald for the ITV1 show's milestone next year.
However, asked if she will be back in an interview with Holy Soap, Jones replied: "Probably not."
The actress admitted that she doesn't miss "the scheduling and hard work" required for Coronation Street. However, she added that she remains friends with some of her former co-stars, including Simon Gregson, who plays Karen's ex-husband Steve.
She commented: "I speak to Simon all the time and on my phone it comes up as Steve McDonald! I miss the people that I was friends with but I don't think Karen will be coming back."
Yesterday, Kevin Kennedy (Curly Watts) also dismissed rumours of a possible comeback for Corrie's 50th.
Additionally, Chris Bisson, who played Vikram Desai, recently said that he isn't expecting to return for the programme's birthday.