The plans were revealed over the weekend by cast member Keith Duffy (Ciaran McCarthy). Producer Phil Collinson previously confirmed that the anniversary week would see a tram crash on to the street.
"Everyone is very excited, if not to say a little nervous, about the prospect of a live episode," a statement said. "But we felt it was fitting to go out live to the nation to celebrate such a prestigious anniversary."
Earlier this month, The People reported that the live episode would show the aftermath of the devastating crash.
Coronation Street previously celebrated its 40th anniversary in 2000 by broadcasting an hour-long live episode.
In February of this year, EastEnders marked its 25th anniversary with a live broadcast, which resolved the soap's Archie Mitchell murder mystery.