In spectacular scenes to mark the soap's 50th anniversary, the dramatic event will cause devastation and heartbreak as the show bids goodbye to some much-loved characters.
Details of who will die and who will suffer injuries are being kept closely under wraps until transmission, as the programme's producers aim to deliver a birthday week full of secrets and surprises.
However, Corrie's cast and crew have now begun filming the milestone episodes - which are to be the most expensive ever made by ITV. Stunt doubles, pyrotechnics specialists, special effects experts and computer-generated imagery are all being used to create what is expected to be the most impressive stunt in the drama's history.
Appearing below, the first behind-the-scenes photos released from filming show the moments preceding and immediately after the explosion - just moments before the tram comes crashing down. One features Jane Danson (Leanne Battersby) and Bill Roache's (Ken Barlow) stunt doubles as they prepare to be thrown to the ground for the explosion scene.
Coronation Street's series producer Phil Collinson commented: "All week we've been filming the exciting and explosive moments that lead to the tram crashing from the viaduct. The early scenes are wonderful and everyone is pulling together through the night to bring the brilliant scripts to life.
"Now it's time to start filming the dramatic scenes that explore the immediate aftermath of this terrible accident. Weatherfield will definitely never be the same again."
Coronation Street's explosion and tram crash will air in December.