The actress, who plays Deirdre Barlow in the ITV1 soap, is said to have found it difficult to watch Becky McDonald (Katherine Kelly) smash Deirdre's living room up with a hammer.
According to the Sunday Mirror, she said: "Look what they are doing to my house... look what they are doing to it. It's so horrible. I can't bear to see this," and was taken to the green room by concerned co-stars to calm down.
"Anne is known to be emotional but these scenes really got to her and she obviously found it very hard to handle seeing the Barlows' house being trashed," a source said. "It's only a set, but in fairness she has spent a large part of her life in that front room.
"She was in a terrible way, absolutely wailing her eyes out. These were some of the most violent scenes many can remember. In all Anne had to take about four or five breaks."
A Corrie spokesman said: "We are unaware of any incident disrupting filming."
The scenes will air next month when Becky launches an attack on rival Tracy Barlow (Kate Ford). Kelly had to wear special safety clothing while filming the plot.
Writers have apparently taken inspiration from The Shining, as Becky shouts "Heeere's Becky!" when smashing through the Barlows' front door. "It sends a chill down the spine," the source added.
Kirkbride allegedly collapsed in tears while on a photoshoot last year. Get the Inside Soap magazine on your iPhone or iPad